Abstract
N-13C-methyl-deoxynojirimycin was synthesized and used in isotope-edited NMR studies to probe the binding site of an alpha-glucosidase. Results from this analysis led to the design and preparation of a novel alpha-glucosidase inhibitor, N-glycyl deoxynojirimycin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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1-Deoxynojirimycin / analogs & derivatives
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Dose-Response Relationship, Drug
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Glucosamine / analogs & derivatives
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Glucosamine / chemical synthesis
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Glycoside Hydrolases / antagonists & inhibitors*
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Glycoside Hydrolases / chemical synthesis*
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Glycoside Hydrolases / chemistry*
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Kinetics
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Magnetic Resonance Spectroscopy
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Multigene Family
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Protein Binding
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Saccharomyces cerevisiae / enzymology
Substances
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1-Deoxynojirimycin
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Glycoside Hydrolases
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Glucosamine
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nojirimycin